products: Overview of ExpDesign Studio

ExpDesign StudioTM is an integrated environment for designing experiments or clinical trials. It is a powerful and user-friendly statistical software product that has integrated 7 main components: Classical Design, Sequential Design, Multi-Stage Design, Dose-Escalation Design, Adaptive Design, Adaptive Trial Minitoring, and Dose-Esclation Trial Monitoring modules. In addition, ExpDesign Randoimizor can generate random variates from different distributions. ExpDesign Toolkit provides features for distributional calculation, confidence intervels, function and data plotting.

How to Design a Classical Trial

  1. Click Group Sequential Design on the toolbar.
  2. Select a method from the list of methods available.
  3. Enter appropriate values for you design (or click Example to see an input-example).
  4. Click on Compute to calculate the sample size required.
  5. Click Report to view the design report.
  6. Click Print to print report.
  7. Click Save to save the design specification or report.









How to Design a Group Sequential Trial

  1. Click Group Sequential Design on the toolbar.
  2. Select a method from the list of methods available.
  3. Enter appropriate values for you design.
  4. Click on Compute to generate the design.
  5. Click Report to view the design report.
  6. Click Print to print the report.
  7. Click Save to save the report.















How to Design an Adaptive Trial

  1. Click Adaptive Design on the toolbar.
  2. Select the Sample-Size Reestimation option in the Type of Design panel.
  3. Select the Proportion option in the Endpoint panel.
  4. Enter appropriate values for the Proportions Under Ha in the Hypothesis panel, the non-inferiority margin for the non-inferiority trial, the One-Sided Alpha, and the Power.
  5. Click Next the Adaptive Design – Step 2 window will appear.
  6. Enter values for the initial number of stages and the Information Time for Analyses.
  7. Choose stopping boundaries using the arrow near the O’Brien or Pocock.
  8. Enter values the N Simulations and the N/group.
  9. Select a statistical method in the panel.
  10. Enter values for the Maximum N/group Allowed for SSR and the Targeted Conditional Power for SSR.
  11. Click Run to start the simulation.
  12. Click Report to view the design report.















How to Design a Multi-Stage Trial

  1. Click Multi-Stage Design on the toolbar.
  2. Select Option for 2-stage Design or 3-stage Design.
  3. Enter appropriate values for your design in the textboxes.
  4. Click Compute to generate the valid designs.
  5. Click Report to view the design report.
  6. Click Print to print the report.
  7. Click Save to save the report.












How to Design a Dose-Escalation Trial

  1. Click Dose-Escalation Design on the toolbar.
  2. Enter appropriate values for your design on the Basic Spec. Panel.
  3. Select Dose-response Model, Escalation Scheme, and Dose Interval.
  4. Click Compute to generate the simulation results.
  5. Click Report to view the design report.
  6. Click Print to print the report.
  7. Click Save to save the report.










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